1、Cooperate with superiors to prepare new lipid molecules/artificial macromolecules/polypeptide protein preparation excipients；
2、Independent purification and characterization of new compounds；
3、Complete other related work assigned by superiors。
1、Doctor degree, rich experience in organic synthesis or controllable polymerization and polymer post-modification or peptide synthesis and protein/polysaccharide post-modification, good experimental operation habits, polymer chemistry, organic chemistry, biochemistry, pharmacy and related majors, should Previous；
2、Familiar with the preparation methods of drug delivery system materials in the research field, and have strong analysis and problem-solving capabilities；
3、Clear organization, strong logical thinking ability, easy to communicate, have a good sense of responsibility and teamwork spirit；
4、Physical health, good psychological quality, good professional ethics and moral integrity, no violations of laws and disciplines and bad records。
Work content:
1. Using various formulation mixing methods (such as microfluidics, jets, T-tubes, etc.), in-depth research on the carrying capacity of various delivery systems for the active ingredients of nucleic acid macromolecules.
2. Participate in the research and development of prescriptions for vaccines;
3. Cooperate with the delivery system development team to prepare and optimize the preparation sample of the new carrier material;
4. Complete other related tasks arranged by the leadership.
Qualifications:
1. Doctor degree, major in pharmacy and nanoscience, with experience in nucleic acid drug nano preparations is preferred;
2. Strong learning ability, strong experimental hands-on ability, rigorous scientific research ideas and good experimental habits.
3. Have good communication skills and teamwork spirit, work proactively, and have a strong sense of responsibility.
Research direction: preparation technology research
Work content:
1. Analyze different delivery system formulations (proportions of different components such as liposomes, polymers, and mRNA) and different preparation processing conditions (such as mixing flow rate in the microfluidic system, continuous phase dispersion ratio, etc.) that have a large effect on nucleic acids. The carrying capacity of molecular active ingredients.
2. Participate in the research and development of prescriptions for vaccines;
3. Cooperate with the delivery system development team to prepare and optimize the preparation sample of the new carrier material;
4. Complete other related tasks arranged by the leadership.
Qualifications:
1. Master's degree or above, major in chemical engineering, physical chemistry, mechanical engineering, fluid mechanics, etc., with biomedical related research experience as a bonus item;
2. Familiar with COMSOL, AutoCAD, Solidworks, Matlab and other modeling analysis software is preferred
3. Strong learning ability, strong experimental hands-on ability, rigorous scientific research ideas and good experimental habits.
4. Have good communication skills and teamwork spirit, be proactive in work, and have a strong sense of responsibility.
Research direction: preparation technology research
Work content:
1. Develop relevant technologies for the crude product of purified preparations, write SOPs and be responsible for transferring to the process department;
2. Complete other related work assigned by superiors.
Qualifications:
1. Master's degree, with experience in purification of biological macromolecules or nano-products, pharmaceutical engineering, pharmacy, chemistry, materials science and other related majors;
2. Familiar with the operation of common purification equipment (such as tangential flow filtration system), have strong hands-on ability, can independently consult literature, and can understand and copy publicly reported cutting-edge nano preparation purification technology;
3. Clear organization, strong logical thinking ability, easy to communicate, have a good sense of responsibility and teamwork spirit.
Research direction: preparation technology research
1. Follow up the pharmacology of vaccine products, the design of pharmacological effects and the result analysis;
2. Responsible for communicating with animal CRO companies and supervising the progress of the project;
3. Cooperate with other positions to complete the pre-clinical research of the new drug project.
1. Doctor degree in biology, medical laboratory, preventive medicine, etc.;
2. Familiar with relevant professional knowledge and experimental skills, and be able to proficiently complete the design of pharmacology and pharmacodynamic experiments and the analysis of results;
3. Work initiative, strong sense of responsibility, good at communication and coordination.
1. According to the plasmid sequence provided by the upstream, carry out the process of amplification and development of the synthesis of mRNA stock solution at the GMP-like level;
2. According to the requirements of the project, make plan formulation, implementation and summary, and report to the superior in time;
3. Write SOPs related to equipment, instruments, operations, data, etc.;
4. Complete other related tasks assigned.
1. Doctor degree, major in biology and pharmacy;
2. Be proficient in molecular biology related experimental operations, be proficient in operating bioreactors and deal with common problems of the instrument;
3. Have GMP awareness and related concepts, and be familiar with aseptic operation and other specifications.
4. Physical and mental health, with team spirit.
Work content:
1. Responsible for the preparation, purification or evaluation of mRNA;
2. Responsible for the sorting of experimental data, timely recording of experimental procedures and data, and participating in the writing of relevant content of the application materials;
3. Cooperate with the project team and the company to complete other related work.
Qualifications:
1. Master's degree or above in molecular biology and biochemistry related majors;
2. Experience in RNA related experiments is preferred;
3. Have good learning ability and a lot of experimental experience;
4. Good English reading and writing skills, and proficient reading of international journal documents;
5. Have good written and oral expression skills, and be good at active communication;
6. Strong sense of responsibility, good professional ethics and teamwork spirit.
Research direction: RNA purification
